cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily
摘要：
Interleukin-1 alpha and -1 beta (IL-1α and IL-1β ) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1α and IL-1β in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.
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关键词：
Animals Mice DNA Receptors, Immunologic Cloning, Molecular Base Sequence Multigene Family Genes, Immunoglobulin Gene Expression Regulation Amino Acid Sequence
DOI：
10.1126/science.2969618
被引量：
年份：
1988
万方医学
Europe PMC
NCBI
JSTOR
Oxford Univ Press
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