Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level 1
摘要：
The nitroimidazoles have been found to selectively sensitize hypoxic cells to the effects of irradiation. The latest in this family of drugs is RO-07-0582, which is able to mimic 80% of the oxygen effect at a concentration of 5 mM by modifying the sensitivity of hypoxic cells to single doses of gamma rays; however, it is not a substitution for oxygen in promoting the repair of sublethal radiation damage between split doses. Studies show that it is a powerful cytotoxic agent as well and selectively operates against hypoxic cells.
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关键词：
n48210* --life sciences--radiation effects on cells-- external source biomedical sciences, applied studies--radiation effects--radiation effects on cells--external source animal cells-- radiosensitivity oxygen-- radiosensitivity effects radiosensitizers-- pharmacology biological radiation effects cell cultures drugs response modifying factors testing
DOI：
10.1148/117.2.453
被引量：
年份：
1975
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