Effects of Apramycin, a Novel Aminoglycoside Antibiotic on Bacterial Protein Synthesis
摘要：
1. The novel aminoglycoside antibiotic apramycin is shown to be a potent inhibitor of protein synthesis in bacteria both invivo and invitro. 2. In cell-free systems from Escherichia coli programmed with poly(U), apramycin induces translation errors, as assayed by incorporation of leucine, isoleucine and serine, although this effect occurs only to a limited extent. 3. Apramycin inhibits the translocation step of protein synthesis both invivo , in protoplasts of Bacillus megaterium , and invitro , in cell-free systems from E. coli. It is proposed that this is the primary inhibitory effect of the drug.
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DOI：
10.1111/j.1432-1033.1979.tb13295.x
被引量：
年份：
2010
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