cdc25+ functions as an inducer in the mitotic control of fission yeast
摘要：
In the fission yeast S. pombe the cdc25 + gene function is required to initiate mitosis. We have cloned the cdc25 + gene and have found that increased cdc25 + expression causes mitosis to initiate at a reduced cell size. This shows that cdc25 + functions as a dosage-dependent inducer in mitotic control, the first such mitotic control element to be specifically identified. DNA sequencing of the cdc25 + gene has shown that it can encode a protein of MW 67,000. Evidence is described showing that cdc25 + functions to counteract the activity of the mitotic inhibitor wee1 +, and indicating that both mitotic control elements act independently to regulate the initiation of mitosis.
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关键词：
Saccharomycetales Schizosaccharomyces Cloning, Molecular Cell Cycle Mitosis Gene Expression Regulation Base Sequence Genes, Fungal Time Factors
DOI：
10.1016/0092-8674(86)90546-5
被引量：
年份：
1986
Elsevier
万方医学
dx.doi.org
Europe PMC
Oxford Univ Press
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