RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
摘要：
Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.
展开
关键词：
Animals Xenopus Humans Mice Cell Line 3T3 Cells Tumor Cells, Cultured Peptides Intracellular Signaling Peptides and Proteins Calcitonin Gene-Related Peptide
DOI：
10.1038/30666
被引量：
年份：
1998
Taylor & Francis
BMJ
Nature
Nature
(全网免费下载)
Wiley
查看更多
doi.org
万方医学
Semantic Scholar
(全网免费下载)
Europe PMC
NCBI
Oxford Univ Press
adsabs.harvard.edu
ResearchGate
ProQuest
ResearchGate
(全网免费下载)
EBSCO
EBSCO
rsif.royalsocietypublishing.org
endocrineconnections.com
jacionline.org
ajpregu.physiology.org
pubget.com
fertstert.org
readcube.com
science-open.com
hyper.ahajournals.org
scienceopen.com
epubs.surrey.ac.uk
pharmrev.aspetjournals.org
hw-f5-embojnl.highwire.org
mysciencework.com
mendeley.com
cheric.org
emboj.embopress.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
