Expedient synthesis of 4- O -methylhonokiol via Suzuki–Miyaura cross-coupling
摘要:
Concise and practical synthesis of 4- O-methylhonokiol was achieved in 34% overall yield. The key features of our synthesis include chemoselective ortho-mono bromination of phenol as well as biaryl formation via Suzuki–Miyaura cross-coupling, in which bromophenol was reacted with potassium aryltrifluoroborate using Pd(OAc) 2 and RuPhos under microwave conditions.
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DOI:
10.1016/j.tet.2011.09.115
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年份:
2011
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2015
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