Neurotrophic and neurotoxic effects of amyloid ?? protein: Reversal by tachykinin neuropeptides
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157
摘要：
The amyloid β protein is deposited in the brains of patients with Alzheimer's disease but its pathogenic role is unknown. In culture, the amyloid β protein was neurotrophic to undifferentiated hippocampal neurons at low concentrations and neurotoxic to mature neurons at higher concentrations. In differentiated neurons, amyloid β protein caused dendritic and axonal retraction followed by neuronal death. A portion of the amyloid β protein (amino acids 25 to 35) mediated both the trophic and toxic effects and was homologous to the tachykinin neuropeptide family. The effects of the amyloid β protein were mimicked by tachykinin antagonists and completely reversed by specific tachykinin agonists. Thus, the amyloid β protein could function as a neurotrophic factor for differentiating neurons, but at high concentrations in mature neurons, as in Alzheimer's disease, could cause neuronal degeneration.
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关键词：
Animals Rats Hippocampus Neurons Cells, Cultured Tachykinins Neurotoxins Amino Acid Sequence Molecular Sequence Data Embryo, Mammalian
DOI：
10.1126/science.2218531
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年份：
1990
万方医学
万方医学
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