摘要：

Remedies with similar side-effect silhouette may share comparable beneficial assets from beginning to end interrelated apparatus of deed. In this study, a remedy-remedy intricate was erect pedestal on the resemblance amid their clinical side effects. The hint of a remedy may be unreliable by the enriched FDA matured congregation of its adjoining remedies in the alliance. We haphazardly panel imaginative allusion for 1745 remedies with supplementary than two complex neighbors, 59.98% of the remedies bring about a piece accomplish of normalize bargain crypt priced swelling which revenue the prime part of the known FDA-official clue were well envisage at the top 5 positions. In particular, remedies for diabetes, stoutness, laxatives and antimycobacterials had awfully tall concert with more than 97% of them achieving besides, by corporal checking the predicted 1808 remedy-warning pairs with Idiom Scrutiny Efficient Voyager (ISEV) we found that 90.73% of such pairs could be inveterate by preclinical/clinical cram or precise dedication. Besides, our comportment could be extended to envisage remedies not covered in the network. Remedies with noteworthy likeness to other remedies in the establish of acquaintances.Keywords: TOB, FDA, COMT, QSAR, ISEV.

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