Epidermal Growth Factor-mediated Apoptosis of MDA-MB-468 Human Breast Cancer Cells
摘要：
MDA-MB-468 human breast cancer cells lack estrogen receptors, overexpress epidermal growth factor (EGF) receptors, and are growth inhibited by EGF. We show that treatment of MDA-MB-468 cells with EGF leads to inhibition of cell proliferation, fragmentation of DNA into nucleosomal oligomers, and the development of apoptotic morphology. This treatment is associated with increased expression of c-myc, c-fos, jun family members, and transforming growth factor beta 1 mRNA and with partial proteolytic cleavage of poly(ADP-ribose) polymerase and lamin B. The observation that EGF can mediate apoptosis in EGF receptor-overexpressing cells has important implications for clinical efforts directed at the EGF receptor.
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关键词：
Tumor Cells, Cultured Humans Breast Neoplasms Epidermal Growth Factor Poly(ADP-ribose) Polymerases Proto-Oncogene Proteins c-myc DNA, Neoplasm Cell Division Apoptosis Cell Survival
DOI：
10.1016/0165-4608(94)90231-3
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年份：
1994
万方医学
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