Cardioselective anti-ischemic ATP-sensitive potassium channel openers
摘要：
A series of halo- and nitro-substituted analogues of N-(2-aminoethyl)benzamide has been synthesized. All of the compounds are competitive, time-dependent inhibitors of monoamine oxidase-B (MAO-B), but upon dialysis complete return of enzyme activity is observed for all compounds. Therefore, these are mechanism-based reversible inhibitors of MAO-B. The relative potencies of the compounds are rationalized in terms of steric and hydrophobic effects.
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关键词：
CLASS SEPARATION EUCLIDEAN DISTANCE PRINCIPAL COMPONENT ANALYSIS DISTANCE MATRIX PATTERN RECOGNITION
DOI：
10.1021/jm00076a027
被引量：
年份：
1993
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