Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
摘要：
Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody. The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface IgM while continuing to express high levels of surface IgD. These findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance.
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关键词：
Animals Mice, Inbred C57BL Mice B-Lymphocytes T-Lymphocytes Autoimmune Diseases Immunoglobulin D Immunoglobulin M Muramidase Antibodies
DOI：
10.1038/334676a0
被引量：
年份：
1988
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