The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver.
摘要：
Hydrogen sulfide, like nitric oxide, was best known as a toxic pollutant before becoming recognized as a key regulator of several physiologic processes. In recent years, evidence has accumulated to suggest important roles for hydrogen sulfide as a mediator of several aspects of gastrointestinal and liver function. Moreover, alterations in hydrogen sulfide production could contribute to disorders of the gastrointestinal tract and liver. For example, nonsteroidal anti-inflammatory drugs can reduce production of hydrogen sulfide in the stomach, and this has been shown to contribute to the generation of mucosal injury. Hydrogen sulfide has also been shown to play a key role in modulation of visceral hyperalgesia. Inhibitors of hydrogen sulfide synthesis and drugs that can generate safe levels of hydrogen sulfide in vivo have been developed and are permitting interventional studies in experimental models and, in the near future, humans.
展开
关键词：
ASCalanine, serine, and cysteine-preferring alanine, serine, and cysteine-preferring CBScystathionine β-synthase cystathionine β-synthase CSEcystathionine-γ-lyase cystathionine-γ-lyase COXcyclooxygenase cyclooxygenase NSAIDnonsteroidal anti-inflammatory drug nonsteroidal anti-inflammatory drug
DOI：
10.1053/j.gastro.2006.02.033
被引量：
年份：
2006
Elsevier
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
万方医学
万方医学
查看更多
dx.doi.org
Ingenta
NCBI
NCBI
Europe PMC
NRC Research Press
ResearchGate
(全网免费下载)
ResearchGate
Citeseer
Citeseer
(全网免费下载)
gastrojournal.org
(全网免费下载)
cghjournal.org
onAcademic
deepdyve.com
ajpgi.physiology.org
frontiersin.org
core.ac.uk
gastrojournal.org
pubfacts.com
d.scholar.cnki.net
science-open.com
www.socolar.com
mysciencework.com
cghjournal.org
(全网免费下载)
mendeley.com
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
cghjournal.org
(全网免费下载)
gastrojournal.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
