Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin
摘要:
A mutant d-2-deoxyribose-5-phosphate aldolase (DERA), Ser238Asp, was used to prepare β-hydroxy-δ-lactol synthons and a key intermediate for atorvastatin synthesis.
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DOI:
10.1016/j.tetlet.2004.01.110
被引量:
年份:
2004
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