Anti-HIV activity of quassinoids

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作者：

M Okano，N Fukamiya，K Tagahara，M Cosentino，TY Lee，S Morris-Natschke，KH Lee

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摘要：

Eighteen quassinoid glycosides and nine known quassinoids were tested for inhibitory activity against HIV replication in H9 lymphocytic cells. Of the compounds tested, shinjulactone C (20) demonstrated the highest anti-HIV activity (EC= 10.6 μM) in the absence of cytotoxicity with a therapeutic index of >25.

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关键词：

toxicity, linfocitos, BRUCEA ANTIDYSENTERICA, QUASSINOIDS, propiedades medicinales, antiviral agents, triterpenoids, drug plants, experimentacion in vitro, composicion quimica, AILANTHUS ALTISSIMA, glycosides, plante pesticide, pesticide crops, toxicite, toxicidad, BRUCEA JAVANICA, plante medicinale, glicosidos, composition chimique, lymphocytes, mankind, propiedades antimicrobianas, medicinal properties, plantas medicinales, glycoside, experimentation in vitro, herpetoviridae, lymphocyte, triterpenoidos, ANTIVIRAL PROPERTIES, propriete antimicrobienne, HUMAN IMMUNODEFICIENCY VIRUS, BRUCEA, simaroubaceae, in vitro experimentation, triterpenoide, plantas plaguicidas, genre humain, ailanthus, antiviral, viricidas, antimicrobial properties, propriete pharmacologique, genero humano, CYTOTOXICITY, chemical composition

DOI：

10.1016/0960-894X(96)00096-0

被引量：

101

年份：

1996