Drugs which inhibit prostaglandin biosynthesis.

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摘要：

3 main purposes are expressed in this review of drugs which inhibit prostaglandin (PG) synthesis in vivo: 1) to review comprehensively all types of PG synthetase inhibitors; 2) to indicate which inhibitors are most suitable for investigating biological functions of PGs; and 3) to stimulate interest in further research in the field of PG synthetase inhibitors as therapeutic agents. The nomenclature of PG is given in brief. Chemistry of PG biosynthesis and distribution of PG synthetase are outlined. Substrate analogs and other fatty acids which inhibit PG biosynthesis are discussed. Aspirin-like drugs and other pharmacological agents (such as indomethacin) that inhibit PG biosynthesis are discussed in terms of mechanism of action duration of action and structure-activity relationships. Basically 3 classes of compounds inhibit PG synthetase: 1) substrate analogs; 2) aspirin-like drugs; and 3) diverse agents such as metal ions antioxidants and nuycleotides. Inhibition of PG dehydrogenase is less clear-cut. Only polyphloretin phosphate shows a direct ability to inhibit PG dehydrogenase and this agent deserves further investigation as a PG blocking agent.

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关键词：

Prostaglandins Enzymes Literature Review Endocrine System Physiology Biology Enzymes and Enzyme Inhibitors

DOI：

10.1021/bm300669x

被引量：

2455

年份：

1974