摘要：

Phamaceutical compositions containing surface modified nanoparticulates naproxen compressed into tablets exhibit increased rate of dissolution $i(in vitro) and $i(in vivo) when compared to conventional microparticulate formulations of naproxen. In addition they provide for fast absorption decreased variability in absorption and decreases the fed/fasted variability in absorption. There is also provided a method of preparing the above-described particles and tablets containing said particles comprising the steps of: a) dispersing powdery naproxen in a liquid dispersion medium and wet grinding the naproxen in the presence of rigid grinding media to obtain nanoparticles of naproxen and b1) compresssing the so-obtained nanoparticles into tablets using a pharmaceutically acceptable carrier, or b2) compacting the so-obtained nanoparticles into tablets using a pharmaceutically acceptable carrier.

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