EMT: When epithelial cells decide to become mesenchymal-like cells

来自 EBSCO

阅读量:

300

作者:

KalluriRaghu

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摘要:

Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of EMT in adults but is absent during embryonic development. As highlighted in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial cancer cells. Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences.

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DOI:

10.1172/JCI39675

被引量:

1521

年份:

2009

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2013
被引量:235

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