Neuron–glia metabolic coupling and plasticity
摘要：
The focus of the current research projects in my laboratory revolves around the question of metabolic plasticity of neuronglia coupling. Our hypothesis is that behavioural conditions, such as for example learning or the sleepwake cycle, in which synaptic plasticity is well documented, or during specific pathological conditions, are accompanied by changes in the regulation of energy metabolism of astrocytes. We have indeed observed that the metabolic profile of astrocytes is modified during the sleepwake cycle and during conditions mimicking neuroinflammation in the presence or absence of amyloid-. The effect of amyloid- on energy metabolism is dependent on its state of aggregation and on internalization of the peptide by astrocytes. Distinct patterns of metabolic activity could be observed during the learning and recall phases in a spatial learning task. Gene expression analysis in activated areas, notably hippocampous and retrosplenial cortex, demonstrated that the expression levels of several genes implicated in astrocyteneuron metabolic coupling are enhanced by learning. Regarding metabolic plasticity during the sleepwake cycle, we have observed that the level of expression of a panel of selected genes, which we know are key for neuronglia metabolic coupling, is modulated by sleep deprivation.
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DOI：
10.1113/expphysiol.2010.053157
被引量：
年份：
2011
Elsevier
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