A NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION
摘要：
AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.
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关键词：
Animals Mice Streptomyces Alkaloids Microbial Sensitivity Tests Lethal Dose 50 Chemistry Fermentation Chemical Phenomena Time Factors
DOI：
10.7164/antibiotics.30.275
被引量：
年份：
1977
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