Isosteviol-amino Acid Conjugates as Highly Efficient Organocatalysts for the Asymmetric One-pot Three-component Mannich Reactions
摘要：
Isosteviol-amino acid conjugates were synthesized and used as chiral catalysts for the asymmetric three-component Mannich reaction with hydroxyacetone as donor molecule. Good yields (up to 98%) and excellent stereoselectivities (up to 97:3 dr and 99% ee) were achieved in a short reaction time. In addition, syn- or anti-configurations of -hydroxy--amino carbonyl compounds were obtained as main products with different chiral catalysts.
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DOI：
10.1002/cjoc.201180272
被引量：
年份：
2011
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