Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.
摘要：
Arousal and anxiety are behavioral responses that involve complex neurocircuitries and multiple neurochemical components. Here, we report that a neuropeptide, neuropeptide S (NPS), potently modulates wakefulness and could also regulate anxiety. NPS acts by activating its cognate receptor (NPSR) and inducing mobilization of intracellular Ca2+. The NPSR mRNA is widely distributed in the brain, including the amygdala and the midline thalamic nuclei. Central administration of NPS increases locomotor activity in mice and decreases paradoxical (REM) sleep and slow wave sleep in rats. NPS was further shown to produce anxiolytic-like effects in mice exposed to four different stressful paradigms. Interestingly, NPS is expressed in a previously undefined cluster of cells located between the locus coeruleus (LC) and Barrington's nucleus. These results indicate that NPS could be a new modulator of arousal and anxiety. They also show that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters.
展开
DOI：
10.1016/j.neuron.2004.08.005
被引量：
年份：
2004
Elsevier
(全网免费下载)
Elsevier
国家科技图书文献中心
(权威机构)
万方
Semantic Scholar
(全网免费下载)
查看更多
Semantic Scholar
万方医学
掌桥科研
dx.doi.org
Oxford Univ Press
NCBI
NCBI
Europe PMC
ProQuest
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
jacionline.org
infona.pl
delecea.stanford.edu
(全网免费下载)
mdanderson.influuent.utsystem.edu
core.ac.uk
(全网免费下载)
usdbiology.com
(全网免费下载)
d.scholar.cnki.net
rsob.royalsocietypublishing.org
yadda.icm.edu.pl
mysciencework.com
pubfacts.com
ajplung.physiology.org
mendeley.com
bvsalud.org
usdbiology.com
(全网免费下载)
f1000.com
med.stanford.edu
g3journal.org
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
ResearchGate
(全网免费下载)
usdbiology.com
(全网免费下载)
core.ac.uk
(全网免费下载)
delecea.stanford.edu
(全网免费下载)
usdbiology.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
