Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

Mice homozygous for the recessive allelic mutation motheaten (me) or viable motheaten (mev) on chromosome 6 develop severe defects in hematopoiesis. In thi...

LD Shultz，PA Schweitzer，TV Rajan，... - 《Cell》

Expression cloning of the murine erythropoietin receptor.

Two independent cDNA clones encoding the erythropoietin receptor (EPO-R) were isolated from a pXM expression library made from uninduced murine erythroleuk...

 - 《Cell》

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

Interleukin 3 (IL-3) regulates the proliferation and differentiation of hematopoietic cells. Although the IL-3 receptor chains lack kinase catalytic domain...

O Silvennoinen，BA Witthuhn，FW Quelle，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mi...

Hematopoietic cell phosphatase (HCP) is a tyrosine phosphatase with two Src homology 2 (SH2) domains that is predominantly expressed in hematopoietic cells...

T Yi，AL Mui，G Krystal，... - 《Mol Cell Bilo》

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

The receptors for erythropoietin and other cytokines constitute a new superfamily. They have no tyrosine-kinase or other enzyme motif and their signal-tran...

A Yoshimura，G Longmore，HF Lodish - 《Nature》

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

Mice with the recessive motheaten (me) or the allelic viable motheaten (mev) mutations express a severe autoimmune and immunodeficiency syndrome. We have shown that the basic defect in these mice involves lesions in the gene which encode...

H Wo Tsui，KA Siminovitch，L De Souza，... - 《Nature Genetics》

SH2/SH3 signaling proteins.

SH2 and SH3 domains are small protein modules that mediate protein-protein interactions in signal transduction pathways that are activated by protein tyros...

J Schlessinger - 《Current Opinion in Genetics & Development》

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated...

Demonstrates that erythropoietin (EPO) induces tyrosin phosphorylation of JAK2 kinase. Activation of in vitro phosphorylation; Correlation with the inducti...

Witthuhn，Bruce，A.，... - 《Cell》

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr)-containing sequences. We r...

Z Songyang，SE Shoelson，J Mcglade，... - 《Mol.cell.biol》

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mi...

Hematopoietic cell phosphatase (HCP) is a tyrosine phosphatase with two Src homology 2 (SH2) domains that is predominantly expressed in hematopoietic cells...

T Yi，AL Mui，G Krystal，... - 《Molecular & Cellular Biology》