CXCL13 Is Required for B1 Cell Homing, Natural Antibody Production, and Body Cavity Immunity
摘要：
B1 cells are a predominant cell type in body cavities and an important source of natural antibody. Here we report that in mice lacking the chemokine, CXCL13, B1 cells are deficient in peritoneal and pleural cavities but not in spleen. CXCL13 is produced by cells in the omentum and by peritoneal macrophages, and in adoptive transfers, B1 cells home to the omentum and the peritoneal cavity in a CXCL13-dependent manner. CXCL13 mice are deficient in preexisting phosphorylcholine (PC)-specific antibodies and in their ability to mount an anti-PC response to peritoneal streptococcal antigen. These findings provide insight into the mechanism of B1 cell homing and establish a critical role for B1 cell compartmentalization in the production of natural antibodies and for body cavity immunity.
展开
关键词：
Antibody Formation B-Lymphocytes Chemokines, CXC Omentum Peritoneal Cavity 抗体生成 B淋巴细胞 趋化细胞因子类, CXC 网膜 腹腔
DOI：
10.1016/S1074-7613(01)00257-6
被引量：
年份：
2002
Elsevier
(全网免费下载)
Elsevier
国家科技图书文献中心
(权威机构)
掌桥科研
万方医学
查看更多
Ingenta
dx.doi.org
Oxford Univ Press
NCBI
NCBI
Cell Press
Europe PMC
ProQuest
EureKaMag.com
(全网免费下载)
ResearchGate
EBSCO
deepdyve.com
mendeley.com
jimmunol.org
f1000.com
yadda.icm.edu.pl
infona.pl
onAcademic
bmlsearch.com
www.socolar.com
mysciencework.com
yadda.icm.edu.pl
(全网免费下载)
jacionline.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
