The age-related accumulation of protein carbonyl in rat liver correlates with the age-related decline in liver proteolytic activities.

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作者：

V Simona，P Cristina，D Alessio，C Gabriella，M Matilde，G Zina，P Maria，B Ettore

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摘要：

Increases of protein in animal tissues have been associated with the process. So far, the accumulation of oxidized proteins, highly susceptible to proteolysis, has been attributed to age-related changes in proteasomal . in protein was monitored in six different tissues of male fed ad libitum up to the age of 27 months, and of 24 and 27-month-old subjected to anti-diet restriction (every-other-day feeding ad libitum). activities and liver lysosomal proteolysis were studied. The levels of protein were significantly different in different tissues, and quite stable throughout life; accumulation was restricted to liver tissue very late in life, between ages 24 and 27 months; was fully prevented by diet restriction; was not accompanied by any diet-restriction-sensitive decline of activity; and was accompanied by a dramatic age-related decline in lysosomal proteolysis that was partially prevented by anti-diet restriction. No correlation was found between levels of activity and levels of protein in the different tissues from younger . It is concluded that the process of , a well-known mechanism for cell maintenance, may deserve more interest in studies.

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关键词：

Animals Rats Muscle, Skeletal Liver Pancreas Kidney Heart Ventricles Valine Proteins Analysis of Variance