Colorimetric Determination of Carboxylic Acid Derivatives as Hydroxamic Acids

来自 ACS

阅读量:

29

作者:

V GoldenbergPE Spoerri

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摘要:

Aqueous alkaline hydroxylamine is widely used to form hydroxamic acids which may be estimated by their color reaction with ferric ion, in the analytical determination of carboxylic acid derivatives. This study determined the influence of substituents on the ease of hydroxamic acid formation by monocarboxylic acid derivatives. The esters tested required 2 to 120 minutes for maximum hydroxamic acid formation. The data show a correlation beween structure and rate of hydroxamic acid formation. Bulky and electron-donating groups inhibit hydroxamic acid formation by substituted benzoic acid esters. Replacement of the hydrogen atoms of formamide by a methyl or phenyl group results in decreased rate of hydroxamic acid formation. In setting up the conditions for the determination of α-hydroxy, α-amino, and α-chloro aliphatic esters as hydroxamic acids, the hypochromic effect of these substituents must be considered.

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DOI:

10.1021/ac60140a008

被引量:

53

年份:

1958

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1971
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