Enantio-reversal in Candida rugosa lipase-catalyzed esterification of 3-hydroxybutyric acid
摘要:
Candida rugosa lipase (CRL)-catalyzed esterification of racemic 3-hydroxybutyric acid with different nucleophilic alcohols was studied. The alcohol chain length was found to have a profound role in the enantioselectivity of the reaction. As compared to the esterification with 1-butanol, use of longer alcohols surprisingly led to an enantio-reversal. Under optimized condition, the ( R)-ester with 95–98% enantiomeric excess (ee) was obtained when the esterification was carried out with 1-hexanol and 1-octanol in the presence of freshly activated molecular sieve 4 .
展开
DOI:
10.1016/S1381-1177(00)00095-3
被引量:
年份:
2012
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用!