) gene in pancreatic adenocarcinoma
摘要：
Thegene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic deletions of 9p21–p22 in 85% of pancreatic adenocarcinomas. Analysis ofin pancreatic carcinomas (27 xenografts and 10 cell lines) showed homozygous deletions in 15 (41%) and sequence changes in 14 (38%). These included eight point mutations (four nonsense, two missense and two splice site mutations) and six deletions/ insertions, all accompanied by loss of the wild-type allele. Sequencing offrom primary tumours confirmed the mutations. Coexistent inactivations of bothandwas common and suggests that abnormal regulation of cyclin-dependent kinases may play an important role in the biology of pancreatic carcinoma.
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关键词：
Humans Tumor Cells, Cultured Chromosomes, Human, Pair 9 Adenocarcinoma Pancreatic Neoplasms Chromosome Deletion Base Sequence Mutation Genes, p53 Molecular Sequence Data
DOI：
10.1038/ng0994-27
被引量：
年份：
1994
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Nature
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万方医学
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