Transgene and Transposon Silencing in Chlamydomonas reinhardtii by a DEAH-Box RNA Helicase
摘要：
The molecular mechanism(s) responsible for posttranscriptional gene silencing and RNA interference remain poorly understood. We have cloned a gene (Mut6) from the unicellular green alga Chlamydomonas reinhardtii that is required for the silencing of a transgene and two transposon families. Mut6 encodes a protein that is highly homologous to RNA helicases of the DEAH-box family. This protein is necessary for the degradation of certain aberrant RNAs, such as improperly processed transcripts, which are often produced by transposons and some transgenes.
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关键词：
Animals Humans Chlamydomonas reinhardtii RNA Helicases DNA Transposable Elements Retroelements RNA RNA, Messenger Cloning, Molecular Reverse Transcriptase Polymerase Chain Reaction
DOI：
10.1126/science.290.5494.1159
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2000
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