Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor
摘要：
Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of death in animals infected with anthrax. One component of this toxin, lethal factor (LF), is suspected to be a metalloprotease, but no physiological substrates have been identified. Here it is shown that LF is a protease that cleaves the amino terminus of mitogen-activated protein kinase kinases 1 and 2 (MAPKK1 and MAPKK2) and that this cleavage inactivates MAPKK1 and inhibits the MAPK signal transduction pathway. The identification of a cleavage site for LF may facilitate the development of LF inhibitors.
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关键词：
Animals Humans Mice Oocytes Bacillus anthracis Metalloendopeptidases Mitogen-Activated Protein Kinase Kinases MAP Kinase Kinase 2 Recombinant Fusion Proteins Myelin Basic Proteins
DOI：
10.1126/science.280.5364.734
被引量：
年份：
1998
Wiley
万方医学
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