摘要：

Recently several group I grass pollen allergens, such as Phl p 1 from timothy grass (Phleum pratense), some isoforms of Loi p 1 from rye-grass (Lolium perenne), and Sec c 1 from rye (Secale cereale; S. Laffler, unpublished results) have been characterized by molecular cloning techniques1–3 and were found to display a high degree of amino acid (AA) sequence-similiarity. T lymphocytes play an important role in the induction of IgE-synthesis, and therefore in the development of Type I allergy4–6. In this study humoral and cellular responses to recombinant Phl p 1 (from timothy grass) were analyzed. T cell lines (TCL) and T cell clones (TCC) were established to determine T cell epitopes of this allergen. IgE-crossreactivity among pollen allergens of different grass species has been observed on the IgE-level1. We investigated T cell-crossreactivity among grass group I allergens. The knowledge of major and/or crossreacting T cell epitopes of grass pollen allergens2,7 is important for the development of vaccines for immunotherapy (IT) in the future.

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