Serum Levels of Copper and Zinc in Patients with Rheumatoid Arthritis: a Meta-analysis
摘要：
Many publications with conflicting results have evaluated serum levels of copper (Cu) and zinc (Zn) in patients with rheumatoid arthritis (RA). To derive a more precise estimation of the relationship, a meta-analysis was conducted. Relevant published data were retrieved through PubMed, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biomedical Database (CBM) before September 20, 2014. Weighted mean difference (WMD) with a 95% confidence interval (95% CI) was calculated using STATA 11.0. A total of 26 studies, including 1444 RA cases and 1241 healthy controls, were collected in this meta-analysis. Pooled analysis found that patients with RA had a higher serum level of Cu and a lower serum Zn level than the healthy controls (Cu (μg/dl), WMD=31.824, 95% CI=20.334, 43.314; Zn (μg/dl), WMD=12.683, 95% CI=19.783, 5.584). Subgroup analysis showed that ethnicity had influence on the serum level of Cu (μg/dl) (Caucasian, WMD=43.907, 95% CI=35.090, 52.723, P <0.001; Asian, WMD=14.545, 95% CI=12.365, 41.455, P =0.289) and Zn (μg/dl) (Caucasian, WMD=11.038, 95% CI=23.420, 1.344, P =0.081; Asian, WMD=14.179, 95% CI=18.963, 9.394, P <0.001) in RA and healthy controls. No evidence of publication bias was observed. This meta-analysis suggests that increased serum level of Cu and decreased serum level of Zn are generally present in RA patients.
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DOI：
10.1007/s12011-015-0325-4
被引量：
年份：
2015
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