Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
摘要：
HEPATOCELLULAR carcinoma (HCC) is a prevalent cancer in sub-Saharan Africa and eastern Asia. Hepatitis B virus and aflatoxins are risk factors for HCC, but the molecular mechanism of human hepatocellular carcinogenesis is largely unknown. Abnormalities in the structure and expression of the tumour-suppressor gene p53 are frequent in HCC cell lines, and allelic losses from chromosome 17p have been found in HCCs from Chinaand Japan. Here we report on allelic deletions from chromosome 17p and mutations of the p53 gene found in 50% of primary HCCs from southern Africa. Four of five mutations detected were G → T substitutions, with clustering at codon 249. This mutation specificity could reflect exposure to a specific carcinogen, one candidate being aflatoxin B(ref. 7), a food contaminant in Africa, which is both a mutagen that induces G to T substitutionand a liver-specific carcinogen.
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关键词：
Humans Carcinoma, Hepatocellular Liver Neoplasms Chromosome Deletion Oligonucleotides Aflatoxins Polymerase Chain Reaction Base Sequence Mutation Genes, Tumor Suppressor
DOI：
10.1038/350429a0
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