摘要：

To investigate the feasibility of developing a new tenoxicam plaster, the effects of vehicles and penetration enhancers onthein vitro permeation of tenoxicam from a pressure-sensitive adhesive (PSA) matrices across the dorsal hairless mouse skin were studied.Vehicles employed in this study were propylene glycol (PG)-oleyl alcohol (OAI), PG-oleic acid (OA), and diethylene glycolmonoethyl ether (DGME)-propylene glycol monolaurate (PGML) cosolvents with/without fatty acids. In this study, amines suchas triethanolamine (TEA) and tromethamine (TM) were additionally used as a solubilizer. Among PSAs used, Duro-Tak^Θ87–2510 showed much higher release rate than either Duro-Tak^Θ 87-2100 or Duro-Tak^Θ87–2196. The relatively high flux rate was obtained with the formulation of DGME-PGML (40:60, v/v) with 3% OA and 5% TM, andthe flux increased as a function of the dose; the initial flux up to

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