Kinetics of formation of 5′ terminal caps in mRNA
摘要：
A kinetic analysis of the labeling of the methylated components of messenger RNA and heterogeneous nuclear RNA in mouse L cells indicates that the 5′ terminal cap I structures (m 7GpppX mpYp) of mRNA are derived from 5′ terminal cap structures of hnRNA. Most of the hnRNA caps are conserved during processing, whereas only a portion of the internal m 6A residues in hnRNA are conserved. The cap II structures (m 7GpppX mpY mpZp), which constitute the 5′ termini of some mRNAs, arise by a "secondary" methylation that occurs after the mRNAs have entered the cytoplasm. This secondary methylation is apparently restricted to a particular subclass of mRNAs having a high frequency of pyrimidine nucleotides at position Y, a composition at position X which differs from that of the bulk of the cap I-terminated mRNAs, and a relatively slow rate of turnover.
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DOI：
10.1016/0092-8674(76)90156-2
被引量：
年份：
1976
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