SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS
申请(专利)号：
WO2007US63862
申请日期：
2007-03-13
公开/公告号：
WO2007109456A2
公开/公告日期：
2007-09-27
申请(专利权)人：
PHARMACOPEIA, INC.;MURUGESAN, NATESAN;EWING, WILLIAM;GU, ZHENGXIANG;YU, GUIXUE;MACOR, JOHN E.
被引量：
摘要：
The present invention provides N-isoxazolyl biphenyl sulfonamide compounds of Formula (I), wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, and R<SUP>5</SUP> are as defined herein. These compounds are dual angiotensin and endothelin receptor antagonists, and as such are useful in the treatment of conditions such as hypertension and other diseases.
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