Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression

来自 dx.doi.org

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191

作者：

M Yu，H Zheng，K Tsuneyama，H Takahashi，K Nomoto，H Xu，Y Takano

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摘要：

Maspin, a serine protease inhibitor related to the serpin family, can suppress invasion and metastasis of malignancies. To clarify the role of maspin in the genesis and progression of gastric carcinomas, its expression pattern and level were studied by immunohistochemistry on tissue microarrays containing gastric carcinoma (n = ), normal gastric mucosa (n = ), intestinal metaplasia (n = 38), and adenoma (n = 42); and the findings were compared with clinicopathological parameters. Furthermore, maspin expression in the gastric carcinoma cell lines (HCG-27, MKN28, and MKN45) was examined by immunohistochemistry and Western blotting. We found that cytoplasmic and nuclear maspin expression paralleled each other ( > .05). Univariate and multivariate analyses indicated that expression of maspin correlated negatively with cumulative patient survival in gastric carcinoma (

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关键词：

Gastric carcinoma Carcinogenesis

DOI：

10.1016/j.humpath.2006.11.025

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年份：

2007