Oxidative hydrolysis of 1,3-dithiane derivatives to carbonyl compounds using N-halosuccinimide reagents

Specific and effective procedures are described for the conversion of a variety of substituted 1,3-dithianes to carbonyl compounds by means of mercury(II)-promoted hydrolysis or oxidative cleavage by N-bromo- or N-chlorosuccinimide. The ...

EJ Corey，BW Erickson - 《Journal of Organic Chemistry》

ChemInform Abstract: A Simple Method of Dethioacetalization.

2-Monosubstituted 1,3-dithianes such as (I) are cleaved upon treatment with bis(trifluoroacetoxy)iodobenzene in aqueous acetonitrile to give the correspond...

G Stork，K Zhao - 《Cheminform》

A simple method of dethioacetalization

Thioacetals and thioketals can be cleaved to carbonyl compounds in high yields by treatment with bis (trifluoroacetoxy)iodobenzene

Gilbert，Stork，and，... - 《Tetrahedron Letters》

Multicomponent Linchpin Couplings of Silyl Dithianes: Synthesis of the Schreiber C(1628) Trisacetonide Subtarget for Mycoticins A and B

[formula: see text] An efficient synthesis of trisacetonide (+)-11, the Schreiber C(16-28) subtarget for mycoticins A and B, is described. The key syntheti...

AB Smith，SM Pitram - 《Organic Letters》

Total synthesis of dl-camptothecin

Tang CS, Morrow CJ, Rapoport H.

C Tang，H Rapoport - 《Journal of the American Chemical Society》

92 TOTAL SYNTHESIS OF FK506 AND AN FKBP PROBE REAGENT, (C_8, C_9-^C_2)-FK506 : AN INVESTIGATION OF THE FK506/FKBP COMPLEX

Tang CS, Morrow CJ, Rapoport H.

M Nakatsuka，SL Schreiber - Symposium on the Chemistry of Natural Products

Synthesis and Reactivity of 2-(1,3-Dithian-2-yl)indoles. III. Influence of the Indole Protective N-Phenylsulfonyl Group

Formation of the anion of 2-(1,3-dithian-2-yl)indoles was shown to be possible when the indole nitrogen is protected by a p-methoxyphenylsulfonyl group. In...

M Rubiralta，A Diez，I Reig，... - 《Heterocycles》

Synthesis of (-)-slaframine and related indolizidines

An enantioselective synthesis of the indolizidine alkaloid (-)-slaframine 1 is reported. Reductive double cyclization of the azido epoxy tosylate 48 afforded the indolizidine 52, which was converted to (-)-slaframine in two steps. The cy...

WH Pearson，SC Bergmeier，JP Williams - 《Journal of Organic Chemistry》

Pd(0) promoted alkylation of enol phosphates with organoaluminium compounds and its synthetic applications

Keto carbonyl 1,2- and 1,3-transpositions with and without alkylation of the substrate are described together with ketone synthesis from thiocarboxylic S-ester.

M Sato，K Takai，K Oshima，... - 《Tetrahedron Letters》

α,β-Unsaturated Nitriles: Stereoselective Conjugate Addition Reactions

Dithiane anions undergo intramolecular conjugate additions with α,β-unsaturated nitriles when a dithiane anion is tethered to N-1 of the 3-cyano-1,4,5,6-tetrahydropyridine nucleus. 3-Cyano-1-[2-(1,3-dithianyl-2-yl)ethyl]-1,4,5,6-tetrah...

Fraser F.Fleming，Zahid Husain，D Weaver - 《Journal of Organic Chemistry》