Yeast Mutants Sensitive to Antimicrotubule Drugs Define Three Genes That Affect Microtubule Function
摘要：
Two Saccharomyces cerevisiae genes, CIN8 and KIP1 (a.k.a. CIN9), were identified by their requirement for normal chromosome segregation. Both genes encode polypeptides related to the heavy chain of the microtubule-based force-generating enzyme kinesin. Cin8p was found to be required for pole separation during mitotic spindle assembly at 37 degrees C, although overproduced Kip1p could...
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关键词：
Microtubules Saccharomyces cerevisiae Benomyl Nocodazole Tubulin Restriction Mapping Cloning, Molecular Genetic Complementation Test Drug Resistance, Microbial Phenotype
DOI：
10.1093/genetics/124.2.251
被引量：
年份：
1990
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