TGF-β and BMP signaling in osteoblast differentiation and bone formation.

来自国家科技图书文献中心

喜欢 0

阅读量：

683

作者：

G Chen，C Deng，YP Li

展开

摘要：

pTransforming growth factor-beta (TGF-#946;)/bone morphogenic protein (BMP) signaling is involved in a vast majority of cellular processes and is fundamentally important throughout life. TGF-#946;/BMPs have widely recognized roles in bone formation during mammalian development and exhibit versatile regulatory functions in the body. Signaling transduction by TGF-#946;/BMPs is specifically through both canonical Smad-dependent pathways (TGF-#946;/BMP ligands, receptors and Smads) and non-canonical Smad-independent signaling pathway (ie.g./i p38 mitogen-activated protein kinase pathway, MAPK). Following TGF-#946;/BMP induction, both the Smad and p38 MAPK pathways converge at the Runx2 gene to control mesenchymal precursor cell differentiation. The coordinated activity of Runx2 and TGF-#946;/BMP-activated Smads is critical for formation of the skeleton. Recent advances in molecular and genetic studies using gene targeting in mice enable a better understanding of TGF-#946;/BMP signaling in bone and in the signaling networks underlying osteoblast differentiation and bone formation. This review summarizes the recent advances in our understanding of TGF-#946;/BMP signaling in bone from studies of genetic mouse models and human diseases caused by the disruption of TGF-#946;/BMP signaling. This review also highlights the different modes of cross-talk between TGF-#946;/BMP signaling and the signaling pathways of MAPK, Wnt, Hedgehog, Notch, and FGF in osteoblast differentiation and bone formation./p

展开

关键词：

Osteoblasts Animals Humans Mice Transforming Growth Factor beta Bone Morphogenetic Proteins Signal Transduction Cell Differentiation Gene Expression Regulation Osteogenesis