Targeting Nrf2 Signaling to Combat Chemoresistance

阅读量:

109

作者:

NJ HongK Yong-BeomSY Sang

展开

摘要:

Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that upregulates expression of a battery of genes to combat oxidative and electrophilic stress. Modification of Kelch-like ECH-associated protein 1 (Keap1) by reactive oxygen species stabilizes Nrf2 by escaping from degradation. Nrf2 then binds to antioxidant response elements (AREs) on the promoter region of various genes. Activation of the Keap1-Nrf2-ARE pathway plays critical roles in the chemopreventive effect of various phytochemicals. However, Nrf2 can protect cancer cells from oxidative stress and promote cell proliferation. Moreover, recent studies reveal that activation of the Nrf2 pathway is critical for resistance to chemotherapeutic agents. The aim of this review is to provide a molecular basis for the use of Nrf2 inhibitors in overcoming chemoresistance.

展开

DOI:

10.15430/JCP.2014.19.2.111

被引量:

70

年份:

2014

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

引用走势

2016
被引量:25

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用