Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice

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作者：

MC Martínez，SP Fernandez，LM Loscalzo，C Wasowski，AC Paladini，M Marder，JH Medina，H Viola

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摘要：

The aim of this work was to evaluate if the intraperitoneal administration of the natural compound hesperidin, in a sedative dose, and neo-hesperidin, a hesperidin structural analog that exerts minor sedative effect, were able to induce changes in intracellular signaling cascades in different areas of the brain. The systemic administration of hesperidin produced a marked reduction in the phosphorylation state of extracellular signal-regulated kinases 1/2 (ERK 1/2), but not of Ca +2/calmodulin-dependent protein kinase II α subunit (αCaMKII), in the cerebral cortex, cerebellum and hippocampus. In contrast, neo-hesperidin did not markedly affect the activity of ERK 1/2 in both the cortex and the cerebellum. Taken together, these results demonstrated that intracellular signalling involving a selective decrease in ERK1/2 activation accompanied the depressant action of hesperidin. Even more, the low sedative action of neo-hesperidin correlates with a negligible decrease in phosphorylation state of ERK 1/2 (pERK 1/2), suggesting that low levels of pERK 1/2 in CNS could be a marker of sedative efficacy of flavonoids.

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关键词：

Hesperidin pERK ½ pαCaMKII Sedation Mouse

DOI：

10.1016/j.pbb.2008.12.016

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年份：

2009