摘要：

Exposure of isolated rat hepatocytes to toxic doses of menadione (2-methyl-1,4-naphthoquinone) results in enhanced formation of active oxygen species, depletion of cellular glutathione and protein thiols, and perturbation of intracellular calcium ion homeostasis. An increase in cytosolic Ca<latex>$^{2+}$</latex> concentration, resulting from inhibition of the plasma membrane Ca<latex>$^{2+}$</latex> translocase by menadione metabolism, appears to be critically involved in the development of cytotoxicity.

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