Direct sp3 C-H bond activation adjacent to nitrogen in heterocycles.
摘要：
Activation of sp3C–H bonds adjacent to nitrogen in heterocycles is an attractive transformation that is emerging as a practical method in organic synthesis. Thistutorial reviewaims to summarize the key examples of direct functionalization of nitrogen-containing heterocyclesviametal-mediated and metal-catalyzed processes, which is meant to serve as a foundation for future investigations into this rapidly developing area of research. The review covers functionalization of N-heterocyclesviaα-lithiation with alkyllithium/diamine complexes, α-amino radical formation, metal-catalyzed direct C–H activation, C–H oxidations and oxidative couplings, and metal-catalyzed carbene insertions.
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DOI：
10.1039/b607547a
被引量：
年份：
2007
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