Are epsins a therapeutic target for tumor angiogenesis?
摘要：
Solid tumor growth requires the formation of new blood vessels to supply nutrients and oxygen to the malignant cells; one approach to cancer therapy is to block this process by inhibiting VEGF signaling. In this issue of the JCI, Pasula et al. demonstrate a surprising role of epsins--proteins involved in endocytosis--in tumor angiogenesis via their modulation of VEGF signaling. Their findings suggest that these proteins might represent a new target for the development of cancer therapeutics.
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DOI：
10.1172/JCI66171
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年份：
2012
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来源期刊
Journal of Clinical Investigation
12/3/2012
引用走势
2015
被引量：7
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