IL-22 increases the innate immunity of tissues.
摘要：
Interleukin 22 (IL-22) is mainly produced by activated Th1 cells. The data presented here indicate that neither resting nor activated immune cells express IL-22 receptor, and IL-22 did not have any effects on these cells in vitro and in vivo. In contrast, cells of the skin and the digestive and respiratory systems represent putative targets of this cytokine. The expression of IL-22 receptor in keratinocytes was upregulated by Interferon-γ. In these cells, IL-22 activated STAT3 and directly and transcriptionally increased the expression of β-Defensin 2 and β-Defensin 3. High levels of IL-22 were associated with strongly upregulated β-Defensin expression in skin from patients with T cell-mediated dermatoses. Taken together, IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues.
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关键词：
Immune System Animals Humans Mice beta-Defensins DNA-Binding Proteins Trans-Activators Receptors, Interleukin Interleukins Keratinocytes
DOI：
10.1016/j.immuni.2004.07.007
被引量：
年份：
2004
Elsevier
万方医学
掌桥科研
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Cell Press
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