摘要：

Presents evidence that point mutations in the TNF-related activation protein (TRAP) gene give rise to nonfunctional or defective expression of TRAP on the surface of T cells in patients with X chromosome-linked immunodeficiency with hyper-IgM (HIGM1). Expression of TRAP on the surface of T cells in patients with HIGM1; Polymerase chain reaction; Secretion of immunoglobulin isotypes by cultured peripheral blood lymphocytes (PBL) from individuals with HIGM1; More.

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