Polo-like kinases: conservation and divergence in their functions and regulation.
摘要：
Polo-like kinases (Plks) are potent regulators of M phase that are conserved from yeasts to humans. Their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved despite physical and molecular differences in these processes in disparate organisms. Plks are characterized by their Polo-box domain, which mediates protein interactions. They are additionally controlled by phosphorylation, proteolysis and transcription, depending on the biological context. Plks are now recognized to link cell division to developmental processes and to function in differentiated cells. A comparison of Plk function and regulation between organisms offers insight into the rich variations of cell division.
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关键词：
Animals Cell Cycle Proteins Cell Division Humans Protein-Serine-Threonine Kinases 动物 细胞周期蛋白质类 细胞分裂 蛋白质丝氨酸苏氨酸激酶 原癌基因蛋白质类
DOI：
10.1126/science.276.5314.890
被引量：
年份：
2009
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