Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes.
摘要：
The T lymphocyte–specific protein tyrosine kinase p56 lck (Lck) is an essential component of the TCR-mediated signal transduction complex. Lck knockout mice have reduced numbers of double-positive thymocytes and very few mature single-positive cells, particularly of the CD4 lineage. Here we demonstrate the ability of a tetracycline-based tissue-specific inducible Lck transgene to restore expansion of early thymocytes and maturation of single-positive cells in Lck neg mice upon induction with doxycycline. Restoration of Lck expression is particularly important for positive selection to the CD4 + lineage but has a lesser impact on selection to the CD8 + lineage, suggesting activation of Lck is an important component of the signals involved in lineage choice during thymic differentiation.
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关键词：
Animals Mice, Knockout Mice CD4-Positive T-Lymphocytes Lymphocyte Specific Protein Tyrosine Kinase p56(lck Cell Lineage Cell Differentiation Gene Expression Regulation Antigens, CD4 Mice, Transgenic
DOI：
10.1016/S1074-7613(00)80205-8
被引量：
年份：
2000
Elsevier
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