Highly efficient 4-phenoxy substituted organocatalysts derived from N-prolylsulfonamide for the asymmetric direct aldol reaction on water
摘要:
The introduction of phenoxy groups at the hydroxy function of -arylsulfonyl derivatives of -proline resulted in efficient hydrophobic organocatalysts, which could efficiently catalyze the direct aldol reactions of cyclic ketones with a series of aromatic aldehydes in water with excellent yields (99%), diastereoselectivities (up to 99%) and enantiomeric excess (99%).
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DOI:
10.1016/j.catcom.2008.10.005
被引量:
年份:
2009
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