Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.
摘要：
A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.
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关键词：
Animals Humans Mice Breast Neoplasms Neoplasm Metastasis Ethers Macrolides Piperidones Antineoplastic Agents Biological Products
DOI：
10.1021/ja9101503
被引量：
年份：
2010
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